I've been acquainted with the following
psychoactives compounds:

Depressants & Dissociatives;
Ethanol / EtOH / alcohol, drink, *****
γ-Hydroxybutyric acid / GHB / G, fantasy
β-Phenyl-γ-aminobutyric acid / PhGABA / Phenibut
Dextromethorphan / DXM / Benylin, Robitussin
Morphine / Papaver somniferum / *****
3-Methylmorphine / Codeine
Dihydrocodeine / DHC
Buprenorphine / Subutex, Suboxone
N-Allylnoroxymorphone / Naloxone / Suboxone, Narcan
Tramadol / Ultram
O-Desmethyltramadol/ O-DSMT / Omnitram
Thiopental / Sodium Pentothal
Diazepam / ******
2'-Chlorodiazepam / Ro5-3448 / Diclazepam
4'-Chlorodiazepam / Ro5-4864
Chlordiazepoxide / Librium
Gidazepam, hidazepam
Desalkylgidazepam / Bromonordiazepam
N-Desalkylfluarazepam / Norfluarazepam
Flubromazepam
Alprazolam / Xanax
Bromazolam / XLI-268
Clonazolam, Clonitrazolam / Clam
Etizolam / Etilaam, Etizest
Flualprazolam
Flubromazolam
Zopiclone / Zimovane
Pagoclone
Promethazine / Phenergan
Diphenhydramine / DPH / Benadryl, Nytol
Chlorphenamine, chlorpheniramine / CPM / Piriton
Cetirizine / Zyrtec
Amitriptyline / Elavil
Tianeptine / Coaxil, Stablon
Mirtazapine / Remeron
Quetiapine / Seroquel
Nitrous Oxide / N2O / laughing gas
Amyl Nitrite / Poppers
Ketamine [racemic] / K, Kitty
Esketamine [S-isomer] / Special K
Deschloroketamine / 2'-Oxo-PCM / DCK
N-ethyldeschloroketamine / 2'-Oxo-PCE / O-PCE / Eticyclidone
Deoxymethoxetamine / 3-Me-2′-Oxo-PCE / DMXE
Methoxetamine / 3-MeO-2'-Oxo-PCE / MXE / Mexxy
Hydroxetamine / 3-**-2'-Oxo-PCE / HXE / Hexxy
Methoxpropamine / 2-Oxo-3'-MeO-PCPr / MXPr
Methoxisopropamine / 2-Oxo-3'-MeO-PCiPr / MXiPr
3-Hydroxyphencyclidine / 3-**-***
3-Methoxyphencyclidine / 3-MeO-***
3-Methoxyeticyclidine / 3-MeO-PCE
3-Methyleticyclidine / 3-Me-PCE

Stimulants & Enhancers;
1,3,7-Trimethylxanthine / Caffeine / Coffea, Camellia sinensis / Coffee, Tea
3,7-dimethylxanthine / Theobromine / [constituent of] Chocolate
N-Ethyl-L-glutamine / L-Theanine / [constituent of] Green Tea
Nicotine / Nicotiana / Tobacco, cigarettes, smokes
Ephedrine / Ephedra
Pseudoephedrine / Ephedra, Sudafed
Adrenaline, Epinephrine
Choline bitartrate
L-alpha glycerylphosphorylcholine / Alpha-GPC, Choline alfoscerate
Cytidine 5'-diphosphocholine / CDP-choline, Citicoline
N-Acetylcysteine / NAC
2-Dimethylaminoethyl (4-chlorophenoxy)acetate / Meclofenoxate
N-Phenylacetyl-L-prolylglycine ethyl ester / Omberacetam / Noopept
Coluracetam / BCI-540
4-Phenylpiracetam
Propranolol
(±)-2-Benzhydrylsulfinyleth­anehydroxamic acid / Adrafinil
(±)-2-[(Diphenylmethyl)sulfinyl]acetamide / Modafinil
(–)-2-[(R)-(diphenylmethyl)sulfinyl]acetamide / Armodafinil
α-Methylphenethylamine / Amphetamine, αMP / Speed
N-Methylamphetamine / Methamphetamine / ****
Lisdexamfetamine / Vyvanse, Tyvense, Elvanse
2-Fluoromethamphetamine / 2-FMA
3-Fluoroamphetamine / 3-FA /  PAL-353
4-Fluoroamphetamine / 4-FA, 4-FMP /  PAL-303 / Flux
4-Methoxyamphetamine / PMA, 4-MA / Death
5-Methoxy-2-aminoindane / MEAI, 5-MeO-AI / Chaperone, Pace
Methythiolpropamine / MPA / Blow
3-Fluorophenmetrazine / 3-FPM / PAL-593
Methylphenidate / MPH / Ritalin, Concerta
4-Fluoromethylphenidate / 4F-MPH
4-Fluoroethylphenidate / 4F-EPH
3-Methylmethcathinone / 3-MMC / Metaphedrone
3-Methylethcathinone / 3-MEC
4-Methylmethcathinone / 4-MMC / Mephedrone
4-Methylethcathinone / 4-MEC
3-Chloro-N-tert-butyl-cathinone / Bupropion / Wellbutrin, Zyban
4-Chloromethcathinone / 4-CMC / Clephedrone
4-Fluoromethcathinone / 4-FMC / Flephedrone
4-Fluoro-α-methylaminovalerophenone / 4-Fluoropentedrone / 4-FPD
α-Ethylaminocaprophenone / N-Ethylhexedrone / NEH / Hexen
alpha-Pyrrolidinohexiophenone / α-PHP / PV-7
alpha-Pyrrolidinoisohexaphenone / α-PiHP, α-PHiP
3,4-Methylenedioxy-α-pyrrolidinohexiophenone / MDPHP
3,4-Methyl​enedioxy​pentedrone / βk-MBDP / Pentylone
3,4-Methylenedioxymethcathinone / βk-MDMA / MDMC / Methylone
3,4-Methylenedioxymethamphetamine / MDMA / ecstasy
5-(2-methylaminopropyl)benzofuran / 5-MAPB
6-(2-Aminopropyl)benzofuran / 6-APB / Benzofury
6-(2-Aminopropyl)-2,3-dihydrobenzofuran / 6-APDB / 4-desoxy-MDA
Mesembrine / Sceletium tortuosum, Kanna
Harmine / Peganum harmala / Syrian Rue
3,4,8-Trimethoxyphenanthrene-2,5-diol / Dendrobium nobile
NSI-189
4-chloro-N-(2-morpholin-4-ylethyl)benzamide / Moclobemide
Escitalopram / Cipralex, Lexapro
Fluoxetine / Prozac
Sertraline / Zoloft
Venlafaxine / Effexor
5-Hydroxytryptophan / 5-HTP / Oxitryptan

Hallucinogens & Psychedelics;
Cannabidiol / CBD / Cannabis
Cannabigerol / CBG / Cannabis
Δ9-Tetrahydrocannabinol / THC / Cannabis, Marijuana
Hexahydrocannabinol / HHC
AM-2201 / Synth-'noids, Spice
NM-2201 / CBL-2201
5C-AB-PINICA
Salvinorin A  / Salvia Divinorum / Diviner's Sage
d-Lysergic acid amide / d-Lysergamide / LSA / Ergine
Lysergic acid diethylamide / Lysergide / LSD, LAD / Acid, Lucy
Lysergic acid 2,4-dimethylazetidide / LSZ / Diazedine, Lambda, λ
1-Acetyl-lysergic acid diethylamide / 1A-LSD / ALD-52
1-Propionyl-lysergic acid diethylamide / 1P-LSD
1-Cyclopropionyl-N-Methyl-N-isopropyllysergamide / 1cP-MiPLA
6-Allyl-6-nor-lysergic acid diethylamide / AL-LAD / Aladdin
2,5-Dimethoxy-4-methylamphetamine / DOM / Dominic
2,5-Dimethoxy-4-bromoamphetamine / DOB / Aphrodite
2,5-Dimethoxy-4-chloroamphetamine / DOC / Doctor
2,5-Dimethoxy-4-methylthioamphetamine / DOT / Aleph
2,5-Dimethoxy-4-methyl-α-ethylphenethylamine / 4C-D / Ariadne
2,5-Dimethoxy-4-methylphenethylamine / 2C-D, 2C-M / Matrix
2,5-Dimethoxy-4-ethylphenethylamine / 2C-E / Eternity
2,5-Dimethoxy-4-bromophenethylamine / 2C-B / Nexus
2,5-Dimethoxy-4-chlorophenethylamine / 2C-C / Callisto
2,5-Dimethoxy-4-iodophenethylamine / 2C-I / Infinity
2,5-Dimethoxy-4-methylthiophenethylamine / 2C-T / Tesseract
2,5-Dimethoxy-4-ethylthiophenethylamine / 2C-T-2 / Rosy
2,5-Dimethoxy-4-fluoroethylthiophenethylamine / 2C-T-21 / Aurora
2,5-Dimethoxy-4-bromo-β-keto-phenethylamine / βk-2C-B
2,5-Dimethoxy-4-bromo-β-hydroxy-phenethylamine / βOH-2C-B / BOHB
2,3,6,7-Benzo-dihydro-difuran-8-bromo-ethylamine / 2C-B-FLY
2,5-Dimethoxy-N-(2-methoxybenzyl)-4-bromophenethylamine / 25B
2,5-Dimethoxy-N-(2-methoxybenzyl)-4-chlorophenethylamine / 25C
2,5-Dimethoxy-N-(2-methoxybenzyl)-4-iodophenethylamine / 25I
2,5-Dimethoxy-N-(2-hydroxybenzyl)-4-ethylphenethylamine / 25E-NBOH
3,4-Methylenedioxyamphetamine / MDA / Sass, Sally
3,4,5-Trimethoxyphenethylamine / Mescaline / M
3,5-Dimethoxy-4-ethoxyphenethylamine / Escaline
3,5-Dimethoxy-4-methallyloxyphenethylamine / Methallylescaline / MAL
α-Methyltryptamine / αMT / Indopan
N,N-dimethyltryptamine / DMT / The Spirit
N,N-dipropyltryptamine / DPT / The Light
N,N-Diisopropyltryptamine / DiPT / The Sound
N-Methyl-N-ethyltryptamine / MET / The Colour
N-Methyl-N-propyltryptamine / MPT
N-Ethyl-N-propyltryptamine / EPT
N-Methyl-N-isopropyltryptamine / MiPT / The Touch
4-Hydroxy-dimethyltryptamine / 4-**-DMT / Psilocybe / Psilocin
4-Phosphoryloxy-N,N-dimethyltryptamine / 4-PO-DMT / Psilocybin
4-Acetoxy-dimethyltryptamine / 4-AcO-DMT / Psilacetin
4-Hydroxy-N-methyl-N-ethyltryptamine / 4-**-MET / Metocin
4-Acetoxy-N-methyl-N-ethyltryptamine / 4-AcO-MET / Metacetin
4-Acetyloxy-N,N-dipropyltryptamine / 4-AcO-DPT / Pracetin
4-Acetoxy-N-methyl-N-cyclopropyltryptmine / 4-AcO-McPT
4-Acetoxy-N-methyl-N-isopropyltryptamine / 4-AcO-MiPT / Mipracetin
4-Hydroxy-N-methyl-N-isopropyltryptamine / 4-**-MiPT / Miprocin
5-Methoxy-N,N-dimethyltryptamine / 5-MeO-DMT / The God, The Power
5-Methoxy-N-methethyltryptamine / 5-MeO-MET / The Vision
5-Methoxy-N,N-diallyltryptamine / 5-MeO-DALT / Foxtrot
5-Methoxy-N-diisopropyltryptamine / 5-MeO-DiPT / Foxy
5-Methoxy-N-methyl-N-isopropyltryptamine / 5-MeO-MiPT / Moxy

I thought it right to assess some antidepressants, which philosophers are more inclined to call mood enhancers.
This was during my foray into human enhancement, substances intended to enhance physicality, cognition or mood. Nootropic compounds concern the latter two categories.

The most commonly prescribed mood enhancers are serotonin reuptake inhibitors (SRIs), but it takes over a week for these compounds reach their peak effect.
Thus I approached them with the notion that a limited dosage might point to their character, though not revealing it. These considerations in mind, I set about acquiring a few miscellaneous anti-D's.

Fluoxetine was the first successful selective serotonin re-uptake inhibitor (SSRI), better known by its original brand-name Prozac. Fluoxetine has an acute biological half-life of between 1-3 days. Presence of a trifluoromethyl group on the compound deserves note, I wonder what the presence of electronegative fluorine atoms add to the psychoactive flavor of a compound (subjective effects).
I administered a single dose by mouth, there was some indication of subjective character. Light serotonergic sensations and seemingly benign mood-dampening, there is a ****** towards the positive. Waking headspace relatively uninteresting. Observed hints of oneirogenesis, did not manifest in enough character to be detailed - a sort of vivid, 'pulsive wandering, more pronounced in contrast to its waking character.
Good experiment, interesting results.
Ligand     Ki (nM)   Ki (nM)
Target      Flx            Nflx
SERT        1               19
NET         660           2700
DAT         4180         420
5-HT2A   200           300
5-HT2B    5000         5100
5-HT2C    72.6          91.2
α1             3000         3900
M1            870           1200
M2            2700         4600
M3            1000         760
M4            2900         2600
M5            2700         2200
H1            3250         10000

Sertraline is another popular SSRI, also known by it's original brand-name Zoloft. Sertraline has a variable half-life, on average 26 hours.
It's metabolite, desmethylsertraline, has a half life between 62-104 hours but is a far less potent Serotonin Releasing Agent (SRA).
The presence of two chlorine atoms is interesting. The usual, phenomenal serotonergicity is present and pushing towards the positive.
Some nausea, particularly when hungry (this disappeared after some minestrone soup). Some faintness after physical exertion. This dose did not promote onirogenesis. There was a moment of cognitive distortion when the proportions of a focal object seemed to be growing in-and-out, shifting in size.
Site                 Ki (nM)
SERT              0.15–3.3
NET               420–925
DAT               22–315
5-HT1A       >35,000
5-HT2A          2,207
5-HT2C          2,298
α1A        ­        1900
α1B                 3,500
α1D                 2,500
α2                  477–4,100
D2                  10,700
H1                  24,000
mACh           427–2,100
σ1                   32–57
σ2                   5,297

Escitalopram is an SSRI commonly prescribed for major depression and generalised anxiety. It is the (S)-stereoisomer of citalopram. The biological half-life is of escitalopram is between 27-32 hours.
I administered a dose and thought the phenomenal serotonergicity less apparent than fluoxetine but then gastro-intestinal disturbance was noted, I surmised it has a high affinity for 5-HT2C.
Any oneiric qualities were not readily apparent after a single dose, relatively little visual imagery which is understandable given its lack of affinity for 5-HT2A. I found this to be philosophically interesting. Mood elevation observed in bursts of conversation and as odd sensations, possible mental discomfort.
Ligand,
Recptr     Ki (nM)
SERT       2.5
NET        6,514
5-HT2C   2,531
α1            3,870
M1           1,242
H1           1,973

Venlafaxine is a selective serotonin-norepinephrine reuptake inhibitor (SNRI). Venlafaxine and its metabolites are active for about 11 hours.
Initial subjective effects similar to a very light empathogenic stimulant. Perception of altered attention-span/increased reflexive response; energizing yet paradoxically much yawning.
Ligand,  Vnfx      Dvnfx
Recptr    Ki(nM)  Ki(nM)
SERT  ­    82           40.2
NET       2480        558.4

Tianeptine is a tricyclic antidepressant (TCA) with an unusual mechanism of action. It is an atypical agonist of the μ-opioid receptor and has been described as a (selective) serotonin reuptake enhancer (SRE). It has a short duration as sodium salts [prescribed form] of between 2-4 hours but as sulfate this can be notably extended, some of its metabolites are active for longer than tianeptine itself.
Definitely anxiolytic, quite artificial; possible aphrodisiac. I find its opioid activity dissuading, requires caution.
Site          Ki (nM)
MOR       383–768 (Ki)
                 194 (EC50)
DOR      >10,000 (Ki)
                 37,400 (EC50)
KOR      >10,000 (Ki)
                 100,000 (EC50)
All other transporter/receptor/sub-receptor values are >10,000 (Ki).

Bupropion is a norepinephrine-dopamine reuptake inhibitor (NDRI) with affinity for some nicotinic receptors. Bupropion and its metabolites are active for between 12-36 hours. Interestingly it is a substituted cathinone.
Initial subjective effects similar to a fairly light stimulant. Perception of increased attention-span and improved cognition. It is an onirogen that is neutral in quality, enhancing vivid dreaming (a boon of its nicotinic affinity which is counteracted if the stimulant component impinges on sleep). Completely absent of serotonergicity, curious.
The N-tert-butyl group's effect is most interesting, how it affects metabolism. I took 150mg ******, as extended and as instant release (the latter was more pronounced). Interesting to compare with other cathinones, and curious to think of other bupropiologues (for example, 3-Methyl-N-tert-butyl-methcathinone). A decent compound, probably useful for a range of things beyond its indication.
                        Bupropion    R,R-Hydroxybuprp­n   Threo-hydrobuprpn
AUC               1                     23.8                                  11.2
Half-life         11 h                 19 h                                 31 h
IC50 (μM)
DAT               0.66                  inactive                          47 (rat)
NET               1.85                   9.9                                  16 (rat)
SERT              inactive          inactive               ­            67 (rat)
α3β4 nic         1.8                   6.5                                   14 (rat)
α4β2 nic         12                     31                                   no data
α1β1γδ nic     7.9                    7.6                                  no data

Moclobemide is a reversible inhibitor of monoamine oxidase A (RIMA), its monoamine oxidase inhibition lasts about 8–10 hours and wears off completely by 24 hours. Inhibiting the decomposition of monoamines (e.g. serotonin, norepinephrine and dopamine) increases their accumulation at an extracellular level. It tends to suppress REM sleep and so it lacks oneirogenic properties.
Feeling of well-being, less constrained by the usual anxieties; openness. Relatively unnoticeable side-effects when diet is carefully managed. Made the mistake of eating a cheese and turkey sandwich (i.e. foodstuff rich in tryptophan/tyramine), slight indications of serotonergicity later became apparent when in bed: feelings of overheating and flushing, slight sweating, racing thoughts and anxious discomfort. A reminder of Shulgin's old adage: "there is no casual experiment".
Combination with a select few tryptamines (not 5-MeO-xxT) should be safe and synergistic (perfect for pharmahuasca), but is very dangerous to combine with serotonergic drugs.

Orange capsules of condensed vitamin C
Tumble out onto my cracked,
Outstretched palm,
As I arch my spine towards the bathroom sink,
Scooping lukewarm water from the faucet
Into my half closed mouth-
The tiny pills clog my upturned throat:
Just two of the numerous solutions
To a world too numb
To contest.
I've never felt more alive,
Than when I'm drowning my body
With handfuls of tap water
And magic remedies bottled up and
Marketed to a world
Afraid of growing old.
Lining the wall of local drug stores,
One isle over from office supplies
And scented laundry detergent.
Multicolored, multipurpose-
Labels proclaim the fountain of youth
To anyone alive enough to fear it.
There's never enough of reality
To reach our depleted veins
Through the ever present forms
Of the world. Enough isn't
Enough, until we've convoluted it into a tiny
Plastic oval, and forced it down the throats
Of those well enough to swallow it.
Pharmaceutical companies proclaim their
Daily gospel in the linoleum streets
Of hospital waiting rooms
And local grocery stores,
As I cross my heart and count the
Hours until my next prescribed dose
Of complacency. Who knew happiness
Could have the bitter after taste of
Vitamin B or
The credibility of Zoloft.
The sandman has been replaced by Benadryl,
While creativity lies stagnant
Beneath adderall's indifferent thumb.
Obsession is a 26 letter alphabet,
Strung together by a bunch of deficiencies,
Incoherently droning on
To the burden of Man,
And flickering neon light
Of a drive-thru pharmacy.

Sertraline (Zoloft) is used to treat depression, obsessive-compulsive disorder, panic disorder, anxiety disorders, post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD).*

Why do I feel more empty
when I am full of pills?

Hydrocodone®
Lipitor®
Zithromax®
Zocor®

Zoloft®
Prozac®
Ambien®
­Fosamax®

Coumadin®
Klonopin®
Neurontin®
Naproxen®

Simvastatin
A­lbuterol
Glucophage
Metoprolol

I am hurting
on my knees
Can't afford
any of these!

A little oval
The size of a been
It's green
And I'm not sure if it's taunting me
Or comforting me
But it's there
Staring

It's hard to believe
That something so small
Could change my big world

I know it will dissolve
Into many little workers
Trying to take the wheel of my brain
For my captain is evil
And they want to help me

Please do help me

I've tried everything else

levitation
orgasmation
the highest elevation
barefoot in the rain
feeling no pain
running for hours
there's no higher power
elation
creation
of a new me
I've not yet seen
Rockstar
Energy
absent the caffeine
higher and higher
hour after hour
then,
slam
she's gone
lying bare on the floor
staring at the popcorn, pop on the ceiling
spider-webby nothingness
filling her brain
filling her soul
alone in her body
alone in her thoughts
lead apron-ness covering every inch of her body
emptiness
loneliness
numbness
love
exactly-like-love

$12.83
And some change
That I’ve been waiting for
Shove it deep into my pocket
Next to letters scribbled
Un-alphabetically
On the back of a receipt
Letters destined for a screen
Hypocrisy
Two tacos and a tea
Cat food and Zoloft
All my favorite things
$11.29
Am I happy yet?
Am I happy yet?
Am I happy yet?

You told me so young that pills make you better, I'm thirty nine and still not better
From seizure medicines, to Zoloft, to sleeping pills, and downers my head is unwinding

I became an introvert, paranoid. That girl is smiling, want to go home where it
is quiet. Sent to a program to cope with interpersonal relationships

The only thing is the medicines make me gain weight
Sleep is the only thing that I do right


Check ups are always fun, are you taking your medicines? The right answer is always yes.
How are your moods? I have none Yes I'm taken my pills add this and increase this.

At home always nagged for forgetting my pills so I do as I'm told.
Have some Lithium it likes to eat the liver, have some Zoloft, Effexor and more.

Another day, Did you take your  pills? Yes I did in fact I swallowed them all
I filled my cup, made a hysteria soup. Did you take your pills?

Zoloft,
This is a love letter.
Please do not get this confused.
You & my serotonin became infused.
I love you,
But I love you not.
It's almost like my old self,
That I forgot.

You take away the pain.
Only some of it,
The rest remains.

But I love you more than you know,
You've helped me in ways that don't show.

You are the drug that I've been chasing
Coke,
Acid,
Alcohol,
Need some replacin'..

But-
I hate your manipulation,
The way you think I need you,
Everyday,
No hesitation.

You starve me.
You beat me.
Make me physically weak..

But instead of leaving you,
I take you everyday,
Every week.

Because of you,
I've stopped & smelled the roses,
Had my first smile in awhile,
Took some pictures,
Held some poses.

But yet,
I know this can't go on forever.

I'm not sure when our last kiss will be,
Sometimes I only feel you & me,
Other times I feel the urge to leave

But I'll stay with you for now,
Because I don't know better.

The only reason I'm alive,
Is because you help me survive.

You told me so young that pills make you better, I'm thirty nine and still not better
From seizure medicines, to Zoloft, to sleeping pills, and downers my head is unwinding

I became an introvert, paranoid. That girl is smiling, want to go home where it
is quiet. Sent to a program to cope with interpersonal relationships

The only thing is the medicines make me gain weight
Sleep is the only thing that I do right


Check ups are always fun, are you taking your medicines? The right answer is always yes.
How are your moods? I have none Yes I'm taken my pills add this and increase this.

At home always nagged for forgetting my pills so I do as I'm told.
Have some Lithium it likes to eat the liver, have some Zoloft, Effexor and more.

Another day, Did you take your  pills? Yes I did in fact I swallowed them all
I filled my cup, made a hysteria soup. Did you take your pills?