I thought it right to assess some antidepressants, which philosophers are more inclined to call mood enhancers.
This was during my foray into human enhancement, substances intended to enhance physicality, cognition or mood. Nootropic compounds concern the latter two categories.

The most commonly prescribed mood enhancers are serotonin reuptake inhibitors (SRIs), but it takes over a week for these compounds reach their peak effect.
Thus I approached them with the notion that a limited dosage might point to their character, though not revealing it. These considerations in mind, I set about acquiring a few miscellaneous anti-D's.

Fluoxetine was the first successful selective serotonin re-uptake inhibitor (SSRI), better known by its original brand-name Prozac. Fluoxetine has an acute biological half-life of between 1-3 days. Presence of a trifluoromethyl group on the compound deserves note, I wonder what the presence of electronegative fluorine atoms add to the psychoactive flavor of a compound (subjective effects).
I administered a single dose by mouth, there was some indication of subjective character. Light serotonergic sensations and seemingly benign mood-dampening, there is a ****** towards the positive. Waking headspace relatively uninteresting. Observed hints of oneirogenesis, did not manifest in enough character to be detailed - a sort of vivid, 'pulsive wandering, more pronounced in contrast to its waking character.
Good experiment, interesting results.
Ligand     Ki (nM)   Ki (nM)
Target      Flx            Nflx
SERT        1               19
NET         660           2700
DAT         4180         420
5-HT2A   200           300
5-HT2B    5000         5100
5-HT2C    72.6          91.2
α1             3000         3900
M1            870           1200
M2            2700         4600
M3            1000         760
M4            2900         2600
M5            2700         2200
H1            3250         10000

Sertraline is another popular SSRI, also known by it's original brand-name Zoloft. Sertraline has a variable half-life, on average 26 hours.
It's metabolite, desmethylsertraline, has a half life between 62-104 hours but is a far less potent Serotonin Releasing Agent (SRA).
The presence of two chlorine atoms is interesting. The usual, phenomenal serotonergicity is present and pushing towards the positive.
Some nausea, particularly when hungry (this disappeared after some minestrone soup). Some faintness after physical exertion. This dose did not promote onirogenesis. There was a moment of cognitive distortion when the proportions of a focal object seemed to be growing in-and-out, shifting in size.
Site                 Ki (nM)
SERT              0.15–3.3
NET               420–925
DAT               22–315
5-HT1A       >35,000
5-HT2A          2,207
5-HT2C          2,298
α1A        ­        1900
α1B                 3,500
α1D                 2,500
α2                  477–4,100
D2                  10,700
H1                  24,000
mACh           427–2,100
σ1                   32–57
σ2                   5,297

Escitalopram is an SSRI commonly prescribed for major depression and generalised anxiety. It is the (S)-stereoisomer of citalopram. The biological half-life is of escitalopram is between 27-32 hours.
I administered a dose and thought the phenomenal serotonergicity less apparent than fluoxetine but then gastro-intestinal disturbance was noted, I surmised it has a high affinity for 5-HT2C.
Any oneiric qualities were not readily apparent after a single dose, relatively little visual imagery which is understandable given its lack of affinity for 5-HT2A. I found this to be philosophically interesting. Mood elevation observed in bursts of conversation and as odd sensations, possible mental discomfort.
Ligand,
Recptr     Ki (nM)
SERT       2.5
NET        6,514
5-HT2C   2,531
α1            3,870
M1           1,242
H1           1,973

Venlafaxine is a selective serotonin-norepinephrine reuptake inhibitor (SNRI). Venlafaxine and its metabolites are active for about 11 hours.
Initial subjective effects similar to a very light empathogenic stimulant. Perception of altered attention-span/increased reflexive response; energizing yet paradoxically much yawning.
Ligand,  Vnfx      Dvnfx
Recptr    Ki(nM)  Ki(nM)
SERT  ­    82           40.2
NET       2480        558.4

Tianeptine is a tricyclic antidepressant (TCA) with an unusual mechanism of action. It is an atypical agonist of the μ-opioid receptor and has been described as a (selective) serotonin reuptake enhancer (SRE). It has a short duration as sodium salts [prescribed form] of between 2-4 hours but as sulfate this can be notably extended, some of its metabolites are active for longer than tianeptine itself.
Definitely anxiolytic, quite artificial; possible aphrodisiac. I find its opioid activity dissuading, requires caution.
Site          Ki (nM)
MOR       383–768 (Ki)
                 194 (EC50)
DOR      >10,000 (Ki)
                 37,400 (EC50)
KOR      >10,000 (Ki)
                 100,000 (EC50)
All other transporter/receptor/sub-receptor values are >10,000 (Ki).

Bupropion is a norepinephrine-dopamine reuptake inhibitor (NDRI) with affinity for some nicotinic receptors. Bupropion and its metabolites are active for between 12-36 hours. Interestingly it is a substituted cathinone.
Initial subjective effects similar to a fairly light stimulant. Perception of increased attention-span and improved cognition. It is an onirogen that is neutral in quality, enhancing vivid dreaming (a boon of its nicotinic affinity which is counteracted if the stimulant component impinges on sleep). Completely absent of serotonergicity, curious.
The N-tert-butyl group's effect is most interesting, how it affects metabolism. I took 150mg ******, as extended and as instant release (the latter was more pronounced). Interesting to compare with other cathinones, and curious to think of other bupropiologues (for example, 3-Methyl-N-tert-butyl-methcathinone). A decent compound, probably useful for a range of things beyond its indication.
                        Bupropion    R,R-Hydroxybuprp­n   Threo-hydrobuprpn
AUC               1                     23.8                                  11.2
Half-life         11 h                 19 h                                 31 h
IC50 (μM)
DAT               0.66                  inactive                          47 (rat)
NET               1.85                   9.9                                  16 (rat)
SERT              inactive          inactive               ­            67 (rat)
α3β4 nic         1.8                   6.5                                   14 (rat)
α4β2 nic         12                     31                                   no data
α1β1γδ nic     7.9                    7.6                                  no data

Moclobemide is a reversible inhibitor of monoamine oxidase A (RIMA), its monoamine oxidase inhibition lasts about 8–10 hours and wears off completely by 24 hours. Inhibiting the decomposition of monoamines (e.g. serotonin, norepinephrine and dopamine) increases their accumulation at an extracellular level. It tends to suppress REM sleep and so it lacks oneirogenic properties.
Feeling of well-being, less constrained by the usual anxieties; openness. Relatively unnoticeable side-effects when diet is carefully managed. Made the mistake of eating a cheese and turkey sandwich (i.e. foodstuff rich in tryptophan/tyramine), slight indications of serotonergicity later became apparent when in bed: feelings of overheating and flushing, slight sweating, racing thoughts and anxious discomfort. A reminder of Shulgin's old adage: "there is no casual experiment".
Combination with a select few tryptamines (not 5-MeO-xxT) should be safe and synergistic (perfect for pharmahuasca), but is very dangerous to combine with serotonergic drugs.

Meteoric Buick
Slick *****
Frantic frenetic
Majestic kick
Chick shtick
Shashlik

Nicotinic stick
Lick flick
Hermeneutic heretic
Magnetic rhetoric
Hick logic
Strategic

Plastic music
Tick click
Bucolic Bardic
Peptic druidic
Rustic emetic
Sceptic

Polymeric quirk
Sick trick
Turmeric trimeric
Septic *****
Wick crick
Derrick

I walk into class.
I am alone there...
Because I like
To get to places
Early. I wait for
Group to begin.
People start
Rolling in.

We all all say
Hi and Hello
How are you
And you and
You? All is
Well we each
Say out of
Politeness:
But really,
None of
Us are.
That is why
We attend
Group.

Each of us
Are damaged
In some way,
Or just have
A void in our
Lives. We each
Have a diagnosis,
Or two, or so.

So class begins
Late every day
Like clockwork,
And then it
Takes the entire
Session for one
Person to say
A few things
About themselves,
And we have
A few moments
To make comments
If the counselor
Allows any
Opinion but
Her own be
Expressed.

And then it's
Break time
And we all
Smoke our
Chosen
Poison because
It is scientifically
Proven that most
People with say,
Schizophrenia
Or Schizoaffective
Disorder or Bipolar
Disorder, (any type,)
Are addicted to nicotine
Because our nicotinic
Receptors are out of
Whack.

Then it's back to class,
Which starts late again
And another person
Gets a moment to share
Their uncertainty about
Their lives. And I have
To sit there with the
Answer in my head,
Because I am not
Allowed to speak
Anymore. I was
Told one too many
Times by the
Class that I
Make too
Much sense
To be a group
Member, and
Should teach
The class.

The counselors
Always hate
That sort of
Thing. They really
Hate it when you
Psychoanalyze
Them. Group
Is helpful, despite
It's many short-
Comings. Well,
I guess I better
Continue going,
Because I don't
Want to miss
Out on Jack's
Repeated *******'
About how Jill
Won't listen,
Or how Humpty
Can't lose weight
Despite a balanced
Diet. You know the
Type... A Diet Coke
In one hand, and a
Snickers bar in the
Other. We are all        
     UnBaLaNcE
                           d.

Gonna
After a second
Examining the rise of her
Breast the darker
Pink of an ***** ******
Extending
The length of a second
The wealth of a lucky man.
Gonna
Just take a look slow all round the peak curvatures
Compare the pink
With the almonds the mauves
And cinnamons drink
Of  pallmall nicotinic
Sweats and long pauses
Now
I cull
Annihilate
The culinary incarnate
Etching with a
Claw on rock  her
Taste
Pawn her
Platinum diamond
For a soda and chips

Outside, near the entrance,
a tendril wafts into my nose—
A pleasant olfactory response,
as the molecules are absorbed,
and work into the capillaries,
Traveling through the veins,
Into the heart twice and then the arteries to the brain,
Binding to and activating the nicotinic receptors—
Causing a release of dopamine—
Yes, a runner’s high!
And never mind the downsides,
Even after a 30-year quit.

And yet, I'm glad I quit.